Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer

Autor: Guidantonio Malagoli Tagliazucchi, Anna J. Wiecek, Eloise Withnell, Maria Secrier
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36439-7
Popis: The intermediate states of the epithelial-to-mesenchymal transition (EMT) in cancer require further molecular characterisation. Here, the authors develop a method to evaluate EMT transformation and trajectories in cancer transcriptomics data, characterising EMT macro-states, including a hybrid state, and EMT hallmarks.
Databáze: Directory of Open Access Journals