Association of Community Factors with Hospital-onset Clostridioides (Clostridium) difficile Infection: A Population Based U.S.-wide Study

Autor: Ioannis M. Zacharioudakis, Fainareti N. Zervou, Fadi Shehadeh, Evangelia K. Mylona, Eleftherios Mylonakis
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: EClinicalMedicine, Vol 8, Iss , Pp 12-19 (2019)
Druh dokumentu: article
ISSN: 2589-5370
DOI: 10.1016/j.eclinm.2019.02.001
Popis: Background: Clostridioides (Clostridium) difficile ranks first among the pathogens of hospital-acquired infections with hospital-based preventive strategies being only partially successful in containing its spread. Methods: We performed a spatial statistical analysis to examine the association between population characteristics and parameters of community healthcare practice and delivery with hospital-onset Clostridioides (Clostridium) difficile infection (HO-CDI), using data from the Medicare Hospital Compare, Medicare Provider Utilization Part D, and other databases. Among the areas with the highest HO-CDI rates (“hot spots”), we conducted a geographically weighted regression (GWR) to quantify the effect of the decrease in the modifiable risk factors on the HO-CDI rate. Findings: Percentage of population > 85 years old, community claims of antimicrobial agents and acid suppressants, and density of hospitals and nursing homes within the hospital service areas (HSAs) had a statistically significant association with the HO-CDI incidence (p
Databáze: Directory of Open Access Journals