| Autor: |
E A Archakov, R E Batalov, O R Eshmatov, E F Muslimova, S A Afanasiev, S V Popov |
| Jazyk: |
English<br />Russian |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Байкальский медицинский журнал, Vol 2, Iss 3, Pp 19-20 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2949-0715 |
| DOI: |
10.57256/2949-0715-2023-3-19-20 |
| Popis: |
BACKGROUNDIt is known that the autonomic nervous system plays a significant role in the onset, maintenance and arrest of atrial fibrillation. Its influence is determined by a combination of direct and indirect effects on the special conductive cardiac tissue, myocardium, baroreceptors and cardiac vessels. An indirect indicator of the activity of the sympathoadrenal system is beta-adrenoreactivity of erythrocyte membranes (beta-ARM). It is determined by the distribution density of в-adrenergic receptors on cell membranes and the degree of their affinity for plasma catecholamines.THE AIM OF THE STUDYTo evaluate the level of beta-adrenoreactivity of erythrocyte membranes before and after catheter treatment of atrial fibrillation and its influence on the effectiveness of this treatment.MATERIALS AND METHODSThe study sample included 40 patients with various forms of atrial fibrillation: paroxysmal atrial fibrillation was found in 25 (62.5 %) patients, persistent — in 10 (25.0 %), long-term persistent — in 5 (12.5 %). 13 (22.5 %) out of 40 patients were women. The median age was 49 (44; 55) years. All patients underwent either interventional or radiofrequency or cryoballon ablation of atrial fibrillation. In order to study the level of beta-ARM, blood was taken from a peripheral veinRESULTSCryoballon ablation was performed in 7 patients, radiofrequency ablation — in 33. The overall annual effectiveness of ablation (absence of atrial fibrillation paroxysms) was 71.5 % for cryoballon ablation, 73.5 % — for radiofrequency ablation. Early relapses (up to 3 months after surgery) were more common after cryoballon ablation — in 28.5 % of cases versus 16.3 % after radiofrequency ablation. In the sample, myocarditis was diagnosed in 9 (22.5 %) patients. Beta-ARM value before surgery was 19.16 (12.46; 27.46), 3 days after the surgery — 24.43 (15.38; 33.65), 3 months after the surgery — 20.27 (9.90; 27.71). The influence of betaARM levels at all control points on the overall effectiveness of the catheter procedure and on the development of early relapses of arrhythmia after ablation was assessed. The initial beta-ARM value differed in patients with early and late relapses of arrhythmia (14.28 (12.39; 22.55) and 24.68 (16.20; 39.26), respectively).CONCLUSIONSThe study revealed the dynamics of changes in the level of beta-ARM with an increase in the indicator after surgery and its decrease almost to the initial level 3 months after the surgery. However, it was not possible to identify the influence of the level of erythrocyte membranes beta-ARM on the effectiveness of catheter treatment of atrial fibrillation in patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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