Cell-line dependency in cerebral organoid induction: cautionary observations in Alzheimer’s disease patient-derived induced pluripotent stem cells

Autor:	Ju-Hyun Lee, Geon Yoo, Juhyun Choi, Si-Hyung Park, Hyogeun Shin, Renuka Prasad, Yeunehee Lee, Mee Ryung Ahn, Il-Joo Cho, Woong Sun
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Cerebral organoid Disease modeling Alzheimer’s diseases Cell-to-cell variation Neurology. Diseases of the nervous system RC346-429
Zdroj:	Molecular Brain, Vol 15, Iss 1, Pp 1-5 (2022)
Druh dokumentu:	article
ISSN:	1756-6606
DOI:	10.1186/s13041-022-00928-5
Popis:	Abstract The cerebral organoid (CO) model has been used in the study of various neurodegenerative diseases owing to its physiological implications. However, the CO model may only be representative of certain clinical findings in affected patients, while some features are not recapitulated. In this study, we found that neurons in the CO model from patients with Alzheimer’s disease were less responsive to depolarization, in contrast to previous reports. This difference may be partly attributed to the variations in brain spatial identity depending on the genetic background of the induced pluripotent stem cells. Our current observation raises concerns that the phenotypes observed in the CO model need to be carefully evaluated for their clinical implications.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3203a6ad16f54756b9934e50d1b86d03 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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