Real-World, Non-Interventional, Observational Study of Hydroxyzine Hydrochloride in Chronic Pruritus: a Prospective, Non-Comparative Study

Autor: Jayakar Thomas, Dattatray G. Saple, Hemangi R. Jerajani, Narsimha R. G. Netha, Dhanalakshmi U. Rangasamy, Rashid Shaikh, Ravindra P. Babu, Ishita Powar, Sayalee Mhatre, Santosh Vase, Madhuri Matti Srisha, Suyog Mehta, Rajan Mittal, Shivani Acharya, Sujeet N. Charugulla
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Dermatology and Therapy, Vol 9, Iss 2, Pp 299-308 (2019)
Druh dokumentu: article
ISSN: 2193-8210
2190-9172
DOI: 10.1007/s13555-019-0293-2
Popis: Abstract Introduction Although hydroxyzine is widely used for symptom relief in pruritus, its clinical safety and efficacy data in the Indian setting are scarce. We conducted a study to assess the effectiveness and tolerability of hydroxyzine in the management of Indian patients with chronic pruritus in a real-world setting. Methods This was a prospective, observational, patient-reported outcomes (PRO) study in patients with chronic pruritus due to dermatological causes treated with hydroxyzine as per the clinician’s discretion for a period of up to 12 weeks. The primary outcome was improvement in quality of life from baseline, assessed using the 10-point Dermatology Quality of Life Index (DLQI) at week 12 of the study period. Secondary outcomes were improvement in the pruritus scores (5-D itch scale) at 12 weeks, improvements in the DLQI and 5-D itch scores at 2, 4 and 8 weeks and safety. Results The study included 400 patients (179 males, 221 females) from 7 dermatology centres across India. Of the 400 patients recruited, 391 patients completed at least 2 weeks of treatment. There was significant (p
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