LEFT VENTRICULAR HYPERTROPHY DEVELOPMENT, ASSOCIATED WITH GENETIC POLYMORPHISM OF INFLAMMATORY MEDIATORS
| Autor: | L. O. Minushkina, O. S. Chumakova, N. D. Selezneva, V. A. Evdokimova, V. S. Osmolovskata, K. A. Blagodatskikh, V. V. Nosikov, D. A. Zateyshchikov |
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| Jazyk: | ruština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Российский кардиологический журнал, Vol 0, Iss 10, Pp 23-28 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1560-4071 2618-7620 |
| DOI: | 10.15829/1560-4071-2014-10-23-28 |
| Popis: | Aim. To study the association of polymorphic markers of C-reactive protein genes (CRP), interleukine-6 (IL6), interleukine-10 (IL10), lymphotoxine alpha (LTA) and tumornecrosis factor alpha (TNFA) with LVH in patients with hypertensive disease (AH).Material and methods. Totally 468 patients studied with AH (290 – 62% of men, 178 – 38% of women). Mean age 60,8±11,54 y. o., 49 – with diabetes mellitus 2 type (10,5%), 44 (9,4%) had stroke, 175 (37,3%) – current smokers. LVH was absent in 111 and was found in 357.Results. No any association found for echocardiographic parameters with genotypes C(-3014)T, A(-3872)G, G(-2667)C, A(-5237)G gene CRP, G(-1082) A gene IL10, C(252)T gene LTA и A(-308)G gene TNFA. Allele G carriers of polymorphic marker C(-174)G gene IL6 had significantly more prominent LVMM, comparing to the CC genotype carriers (67,29±4,137 g and 241,5±3,15 g resp., р=0,020), LVMMI(140,3±2,12 g/m 2 and 129,0±3,15 g/m2, р=0,037), peak velocity A (69,6±2,41 m/s и 64,9±1,36 m/s, р=0,007) and relation Е/А (1,18±0,111 и 1,01±0,032 resp., р=0,0001). During multifactorial analysis it was found that LVH in those with AH theris association of G polymorphism C(-174)G gene IL6 and diastolic BP level.Conclusion. As the result of the study the new additional evidence was found for impact of systemic inflammation on left ventricular myocardium hypertrophy. |
| Databáze: | Directory of Open Access Journals |
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