| Autor: |
Ozan Kuduban, Cuneyt Kucur, Ebru Sener, Halis Suleyman, Fatih Akcay |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
The Scientific World Journal, Vol 2013 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1537-744X |
| DOI: |
10.1155/2013/182694 |
| Popis: |
Objective. The aim of this study was to evaluate the effectiveness of thiamine pyrophosphate against cisplatin-induced ototoxicity in guinea pigs. Materials and Methods. Healthy guinea pigs (n=18) were randomly divided into three groups. Group 1 (n=6) received an intraperitoneal injection of saline solution and cisplatin for 7 days, group 2 (n=6) received an intraperitoneal injection of thiamine pyrophosphate and cisplatin for 7 days, and group 3 (n=6) received only intraperitoneal injection of saline for 7 days. The animals in all groups were sacrificed under anesthesia, and their cochleas were harvested for morphological and biochemical observations. Results. In group 1, receiving only cisplatin, cochlear glutathione concentrations, superoxide dismutase, and glutathione peroxidase activities significantly decreased (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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