| Autor: |
Saravana Prabha Poochi, Murugesh Easwaran, Balamuralikrishnan Balasubramanian, Mohan Anbuselvam, Arun Meyyazhagan, Sungkwon Park, Haripriya Kuchi Bhotla, Jeeva Anbuselvam, Vijaya Anand Arumugam, Sasikala Keshavarao, Gopalakrishnan Velliyur Kanniyappan, Manikantan Pappusamy, Tanushri Kaul |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Food Frontiers, Vol 1, Iss 2, Pp 168-179 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2643-8429 |
| DOI: |
10.1002/fft2.29 |
| Popis: |
Abstract Angiotensin converting enzyme 2 (ACE2) and main protease (MPro) are significant target proteins, mainly involved in the attachment of viral genome to host cells and aid in replication of severe acute respiratory syndrome‐coronaviruses or SARS‐CoV genome. In the present study, we identified 11 potent bioactive compounds from ethanolic leaf extract of Ipomoea obscura (L.) by using GC‐MS analysis. These potential bioactive compounds were considered for molecular docking studies against ACE2 and MPro target proteins to determine the antiviral effects against SARS‐COV. Results exhibits that among 11 compounds from I. obscura (L.), urso‐deoxycholic acid, demeclocycline, tetracycline, chlorotetracycline, and ethyl iso‐allocholate had potential viral inhibitory activity. Hence, the present findings suggested that chemical constitution present in I. obscura (L.) will address inhibition of corona viral replication in host cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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