GABAB Receptor Blockade Prevents Antiepileptic Action of Ghrelin in the Rat Hippocampus
| Autor: | Zohreh Ataie, Shirin Babri, Mina Ghahramanian Golzar, Hadi Ebrahimi, Fariba Mirzaie, Gisou Mohaddes |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Advanced Pharmaceutical Bulletin, Vol 3, Iss 2, Pp 353-358 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2228-5881 2251-7308 |
| DOI: | 10.5681/apb.2013.057 |
| Popis: | Purpose: Ghrelin has been shown to have antiepileptic function. However, the underlying mechanisms by which, ghrelin exerts its antiepileptic effects are still unclear. In the present study; we investigated antiepileptic mechanism of ghrelin through GABAB receptors using CGP35348 (selective GABAB receptor antagonist). Methods: Male Wistar rats' hippocampi were bilaterally microinjected with the single dose or 10-day ghrelin (0.3 nmol/μl/side). CGP35348, GABAB receptor antagonist, (12.5 μg/μl/side) or saline injected into the dorsal hippocampus 20 minutes before ghrelin administration. Thirty min after ghrelin microinjection, a single convulsive dose of pentylenetetrazole (PTZ) (50 mg/kg) was injected intraperitoneally (i.p). Afterwards, seizure duration and total seizure score (TSS) were assessed for 30 minutes in all animals. Results: Our results demonstrated that acute and chronic intrahippocampal (i.h.) injection of ghrelin could significantly (p |
| Databáze: | Directory of Open Access Journals |
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