| Autor: |
Vincenzo Rondinelli, Stefania Giglio, Vittorio Focarelli, Raffaele Saraceno, Pasquale Minchella, Maria Gabriella Lepore, Nicola Iiritano, Sandra Castagna, Paolo Opipari, Teresa Alcaro, Antonio Balducci, Rosanna Masciari |
| Jazyk: |
English<br />Italian |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Microbiologia Medica, Vol 27, Iss 1 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
2280-6423 |
| DOI: |
10.4081/mm.2012.2333 |
| Popis: |
Introduction. Endotoxin, a component of the cell wall of Gram-negative bacteria is a major contributor to the pathogenesis of septic shock and multiple organ failure (MOF). Its entry into the bloodstream stimulates monocytes/macrophages which once activated produce and release cytokines, nitric oxide and other mediators that induce systemic inflammation, endothelial damage, organ dysfunction, hypotension (shock) and MOF.The aim of this study is to evaluate the usefulness of a quantitative test for the dosage of endotoxin to determine the risk of severe Gram-negative sepsis. Materials and methods. In the period January 2009 - June 2011 we performed 897 tests for 765 patients, mostly coming from the emergency room and intensive care, of which 328 (43%) women (mean age 53) and 437 (57%) male (mean age 49). Fifty-nine patients, no statistically significant difference in sex, were monitored by an average of two determinations of EA.All patients had procalcitonin values significantly altered.The kit used was EAA (Endotoxin Activity Assay) Estor Company, Milan, which has three ranges of endotoxin activity (EA): low risk of sepsis if |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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