Identification and structural analysis of the tripartite α-pore forming toxin of Aeromonas hydrophila

Autor: Jason S. Wilson, Alicia M. Churchill-Angus, Simon P. Davies, Svetlana E. Sedelnikova, Svetomir B. Tzokov, John B. Rafferty, Per A. Bullough, Claudine Bisson, Patrick J. Baker
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10777-x
Popis: Pore forming toxins (PFTs) form the major group of virulence factors in many pathogenic bacteria. Here the authors identify tripartite α-helical PFTs in pathogenic Gram negative bacteria and structurally characterize AhlABC from Aeromonas hydrophila and propose a model for its pore assembly.
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