The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye

Autor: Anne Wolf, Marc Herb, Michael Schramm, Thomas Langmann
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16400-8
Popis: Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. Here, the authors show that microglia-specific deletion of TSPO and chemical inhibition of TSPO prevent neuroinflammation and vascular damage in a mouse model of AMD.
Databáze: Directory of Open Access Journals