Achieving postprandial glucose control with lixisenatide improves glycemic control in patients with type 2 diabetes on basal insulin: a post-hoc analysis of pooled data

Autor:	Jaime A. Davidson, William Stager, Sachin Paranjape, Rachele Berria, Lawrence A. Leiter
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Type 2 diabetes Lixisenatide Glucagon-like peptide-1 receptor Post-prandial glucose Glycemic targets Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Clinical Diabetes and Endocrinology, Vol 6, Iss 1, Pp 1-7 (2020)
Druh dokumentu:	article
ISSN:	2055-8260
DOI:	10.1186/s40842-019-0088-5
Popis:	Abstract Background To examine the impact on glycemic control of achieving postprandial glucose (PPG) target with lixisenatide, a once-daily glucagon-like peptide-1 receptor agonist approved in the US, in patients with uncontrolled type 2 diabetes (T2D) on basal insulin, an agent that primarily targets fasting plasma glucose. Methods A post hoc pooled analysis was conducted using clinical trial data extracted from the intent-to-treat subpopulation of patients with T2D who participated in the 24-week, phase 3, randomized, double-blind, placebo-controlled, 2-arm parallel-group, multicenter GetGoal-L (NCT00715624), GetGoal-Duo 1 (NCT00975286) and GetGoal-L Asia trials (NCT00866658). Results Data from 587 lixisenatide-treated patients and 484 placebo-treated patients were included. Patients on lixisenatide were more likely to achieve a PPG target of
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2e5a5fd82d6f44e590d28a4c4d912c0e Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ