Evaluation of BSP and DMP1 in hydroxyapatite crab shells used for dental socket preservation
| Autor: | Michael Josef Kridanto Kamadjaja, Sherman Salim, Wiwik Herawati Waluyo, Tengku Natasha Eleena binti Tengku Ahmad Noor |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Dental Journal, Vol 56, Iss 2, Pp 104-108 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1978-3728 2442-9740 |
| DOI: | 10.20473/j.djmkg.v56.i2.p104-108 |
| Popis: | Background: Bone resorption due to tooth extraction leads to unpredictable bone volume for future prosthetics. Crab shells were promoted as a solution to prevent bone resorption, along with an effort to reduce biological waste. Purpose: This study aimed to analyze the expression of bone sialoprotein (BSP) and dentine matrix protein-1 (DMP1) in the wound healing process in tooth-extraction sockets after applying a crab shell-derived hydroxyapatite scaffold. Methods: The subjects (28 Cavia cobaya) were divided into control and treatment groups. The control group was left untreated, while the treatment group received a hydroxyapatite scaffold of Portunus pelagicus shell in the tooth socket. The expression of BSP and DMP1 was determined by immunohistochemical staining on days 7 and 14. One-way analysis of variance and Tukey’s honest significance difference test were used to find the groups with the most significant difference. Results: The highest mean expression of BSP and DMP1 was in the day 14 treatment group, while the lowest was in the day 7 control group. Conclusion: Administering hydroxyapatite scaffold derived from the Portunus pelagicus shell to the post-extraction sockets increased the expression of both BSP and DMP1. |
| Databáze: | Directory of Open Access Journals |
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