Sodium–glucose cotransporters: Functional properties and pharmaceutical potential

Autor:	Ryuhei Sano, Yuichi Shinozaki, Takeshi Ohta
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Antidiabetic drugs Sodium–glucose cotransporter 1 Sodium–glucose cotransporter 2 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Journal of Diabetes Investigation, Vol 11, Iss 4, Pp 770-782 (2020)
Druh dokumentu:	article
ISSN:	2040-1124 2040-1116
DOI:	10.1111/jdi.13255
Popis:	Abstract Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium–glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms. Recently, SGLT1 and SGLT2 have attracted much attention as therapeutic targets for various diseases. This review addresses the basal and functional properties of glucose transporters and SGLTs, and describes the pharmaceutical potential of SGLT1 and SGLT2.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2d4cb81793024764b14e18e9f4187f80 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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