Antiulcerogenic activity of the ethanolic extract of Licania macrophylla Benth

Autor: Priscila Faimann Sales, Patrícia de Almeida Nóbrega, Alessandra Azevedo do Nascimento, Felipe Ricardo Ferreira Brito Corrêa, Giuvanna Nascimento de Veiga Cabral, Eginna Gonçalves da Silva
Jazyk: English<br />Portuguese
Rok vydání: 2019
Předmět:
Zdroj: O Mundo da Saúde, Vol 43, Iss 4, Pp 814-833 (2019)
Druh dokumentu: article
ISSN: 0104-7809
1980-3990
Popis: The Licania macrophylla Benth species, popularly known as “anauerá”, “anuera”, “anoerá”, “ana-wyra” and “wayãpi”, is widely found in the Amazon. Here, riverine communities use different parts of the plant for the treatment of amoebiasis, dysenteric disorders, wound healing and anti-inflammatory actions. The present study aims to investigate the gastroprotective activity of ethanolic extract of L. macrophylla stem bark in experimental animals. For this purpose, different experimental models for gastric ulcer induction were performed, such as absolute ethanol (99.5%), acidified ethanol (60%/0.3M HCl), and the non-steroidal anti-inflammatory drug model (indomethacin). In this study, 25-30g female Swiss mice were used for the absolute and acidified ethanol experimental models, and 200-300g female Wistar rats were used for the non-steroidal anti-inflammatory drug model. Each experimental model was divided into groups of five (5) animals for each tested dose of L. macrophylla extract (100, 250 and 625 mg/kg), as well as for the negative (vehicle) and positive (carbenoxolone) control groups. All administrations were performed orally, with a volume ratio of a maximum of 10 ml/kg body weight for mice and 100 ml/kg for rats. After each experiment, stomachs were evaluated to determine the following parameters: total lesion area, ulcer percentage, ulcerative lesion index, cure percentage. Statistical analysis was performed by one-way ANOVA followed by Dunnett post-test, considering significant values when p
Databáze: Directory of Open Access Journals
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