Trends in pulmonary embolism mortality rates by age group in the United States, 1999–2019

Autor: Ayla Cash, Abdul Mannan Khan Minhas, Vanessa Pasadyn, Salik Nazir, Robert W. Ariss, Rajesh Gupta
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: American Heart Journal Plus, Vol 13, Iss , Pp 100103- (2022)
Druh dokumentu: article
ISSN: 2666-6022
DOI: 10.1016/j.ahjo.2022.100103
Popis: Introduction: Acute pulmonary embolism (PE) is a major cause of mortality in the United States. Recent reports indicate that PE-related mortality rates have increased among individuals younger than 65 years old. It remains unclear whether this increase in PE-related mortality is evenly distributed. A narrowly focused and clinically meaningful age group analysis is necessary. Methods: Death certificate data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database were examined to determine all-cause PE mortality trends from 1999 to 2019 among adults 25–39, 40–54, 55–69, 70–84, and ≥85 years old. The crude death rates for individual years and annual percentage change (APC) were calculated to determine trends. Results: PE-related mortality rates increased among those 25–39, 40–54, and 55–69. Among individuals 25–39 years old, death rate increased from 1.8 to 2.0 (APC 0.7 [95% confidence interval (CI) 0.2 to 1.1]) between 1999 and 2014 and continued to increase from 2.0 to 2.4 (APC 4.1 [95% CI 1.8 to 6.5]) between 2014 and 2019. Among those 40–54 years old, the crude death rate increased from 5.7 to 7.5 (APC 2.0 [95% CI, 1.6 to 2.5]) between 2007 and 2019. Among those 55–69 years old the crude death rate increased from 15.6 to 18.5 (APC 2.2 [95% CI, 1.9 to 2.5]) between 2010 and 2019. Recent death rates decreased or plateaued among individuals older than 70. Conclusions: Individuals younger than 70 years had increase in PE-related mortality between 1999 and 2019 with marked increase among those 25–39 years old.
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