| Autor: |
Jacqueline Córdova‐Gallardo, Froylan David Martínez‐Sánchez, David Medina‐Julio, Martin Edgardo Rojano‐Rodríguez, Luz Sujey Romero‐Loera, Romina Vargas‐Agredano, Nahum Méndez‐Sánchez |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
JGH Open, Vol 8, Iss 9, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2397-9070 |
| DOI: |
10.1002/jgh3.70023 |
| Popis: |
Abstract Background Obesity is a significant risk factor for metabolic‐associated steatotic liver disease (MASLD). The association between Helicobacter pylori (HP) infection and liver fibrosis has not been fully elucidated in patients with obesity and MASLD. Methods This observational retrospective study included clinical and biochemical parameters of patients with obesity undergoing bariatric surgery. HP infection was confirmed by gastric endoscopy, and liver biopsies were performed during surgery. Bivariate and logistic regression analyses were employed to evaluate independent associations with liver fibrosis and steatosis by biopsy. Results The mean age of the subjects was 42 ± 10 years, with 84.7% being women, and they had a mean BMI of 42.97 ± 7.56 kg/m2. Overall, 41.7% of patients had an HP infection. Multiple logistic regression models were conducted to assess the association between HP infection, liver steatosis, and fibrosis by biopsy. HP infection was independently associated with liver fibrosis [OR = 3.164 (95% CI 1.011–9.900)]. Conclusion Biopsy findings associated HP infection with increased liver fibrosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text