| Autor: |
Xia-Fang Chen, Jing Wu, Yi-Dan Zhang, Chen-Xing Zhang, Xu-Ting Chen, Jian-Hua Sun, Tong-Xin Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Pediatrics and Neonatology, Vol 59, Iss 3, Pp 288-295 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1875-9572 |
| DOI: |
10.1016/j.pedneo.2017.09.006 |
| Popis: |
The uncontrolled inflammatory response following infection is closely related to the morbidity and mortality of neonates. Interleukin 6 (IL-6) plays an important role in the pathogenesis and prognosis of this process. To better elucidate the secretion of IL-6 following infection in neonates, we investigated the IL-6 level and mechanism of IL-6/TLR4 signaling pathways. Methods: We compared the IL-6, procalcitonin (PCT), and CRP levels between septic neonates and toddlers. In vitro cord blood samples from healthy term neonates and peripheral venous blood from healthy adult volunteers were collected. Protein expression was analyzed by Western blotting, mRNA expression by real-time PCR and membrane molecule expression by flow cytometry. Results: The IL-6 concentrations were significantly higher in the neonate group than in the toddler group (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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