Success of Crizotinib Combined with Whole-Brain Radiotherapy for Brain Metastases in a Patient with Anaplastic Lymphoma Kinase Rearrangement-Positive Non-Small-Cell Lung Cancer

Autor:	Sachi Okawa, Takuo Shibayama, Atsushi Shimonishi, Jun Nishimura, Taichi Ozeki, Kenji Takada, Hiroe Kayatani, Daisuke Minami, Ken Sato, Keiichi Fujiwara, Toshiro Yonei, Toshio Sato, Manabu Suno
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	ALK rearrangement-positive NSCLC Leptomeningeal carcinomatosis Central nervous system failure Crizotinib Whole-brain radiotherapy Blood-brain barrier permeability Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncology, Vol 11, Iss 3, Pp 777-783 (2018)
Druh dokumentu:	article
ISSN:	1662-6575
DOI:	10.1159/000492150
Popis:	Although crizotinib shows marked antitumor activity in anaplastic lymphoma kinase (ALK) rearrangement-positive non-small-cell lung cancer (NSCLC) patients, all treated patients ultimately develop resistance to this drug. Isolated central nervous system failure without progression at extracranial sites is a common progression pattern in ALK rearrangement-positive NSCLC patients treated with crizotinib. Here, we report the success of crizotinib combined with whole-brain radiotherapy in an ALK rearrangement-positive NSCLC patient who developed leptomeningeal carcinomatosis and progression of multiple brain metastases. Additionally, we focused on the mechanism involved by examining the plasma and cerebrospinal fluid concentrations of crizotinib in the present case.
Databáze:	Directory of Open Access Journals
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