Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker

Autor:	Georgina E. T. Blake, Xiaohui Zhao, Hong wa Yung, Graham J. Burton, Anne C. Ferguson-Smith, Russell S. Hamilton, Erica D. Watson
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Science
Zdroj:	Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Druh dokumentu:	article
ISSN:	2041-1723 87964694
DOI:	10.1038/s41467-021-24036-5
Popis:	Abnormal folate metabolism in mice results in transgenerational epigenetic inheritance of congenital malformations. Here, the authors provide evidence that defective folate metabolism causes germline epigenetic instability and observe multigenerational misexpression of Hira in embryos, implicating Hira transcript levels as a biomarker of maternal phenotypic inheritance.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a2b6f87964694b4bad4140b486ce7efe Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ