| Autor: |
A. Teixeira, T. Felismino, M.D. Donadio, G. Catani, A.L.M. da Silva, R. Weschenfelder, R.D. Peixoto, J.M. O’Connor, A.K. Coutinho, R.P. Riechelmann |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
ESMO Gastrointestinal Oncology, Vol 6, Iss , Pp 100110- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2949-8198 |
| DOI: |
10.1016/j.esmogo.2024.100110 |
| Popis: |
Background: We have previously suggested that concurrent use of capecitabine plus oxaliplatin (CAPOX) and angiotensin receptor blockers (ARBs) significantly increased the risk of severe diarrhea and/or enterocolitis. We conducted a multicenter larger study to validate this finding, adjusting for other risk factors. Patients and methods: This was a retrospective multicenter study of patients with colorectal cancer treated with at least one cycle of CAPOX. The primary endpoint was grade (G) ≥3 diarrhea and/or enterocolitis induced by CAPOX. Unadjusted and adjusted logistic regression models were used to evaluate risk factors for G ≥3 diarrhea and/or enterocolitis. P < 0.05 was deemed significant. Results: From April 2010 to December 2023, 362 patients were included. In univariate analyses, age ≥65 years, right-sided tumors, use of ARBs or angiotensin-converting enzyme inhibitors (ACEi), age-adjusted Charlson Comorbidity Index, and estimated glomerular filtration rate (eGFR) |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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