| Autor: |
Ambika Amblee, MD, Malini Ganesh, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
AACE Clinical Case Reports, Vol 2, Iss 4, Pp ee316-ee320 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2376-0605 |
| DOI: |
10.4158/EP15935.CR |
| Popis: |
ABSTRACT: Objective: To report a case of retroperitoneal fat necrosis (RFN) found after extensive weight loss following left adrenalectomy in a woman with Cushing syndrome.Methods: Case-based review of RFN without pancreatic disorders. We performed a PubMed search using the search term ‘retroperitoneal fat necrosis.’Results: A 33-year-old woman with Cushing syndrome developed bilateral fat-containing infiltrative soft-tissue neoplasms in the perinephric space, measuring 5.0 × 7.5 cm (right) and 7.8 × 8.1 cm (left), with numerous enlarged retroperitoneal lymph nodes and fat stranding, 10 months post–left adrenalectomy for a 9-cm adrenal cortical neoplasm of uncertain malignant potential. Both computed tomography (CT)-guided core-needle biopsy followed by exploratory laparotomy with biopsy of the retroperitoneal masses showed that it was fat necrosis (FN) surrounded by a narrow rim of fibrous tissue with chronic inflammation. No further intervention was initiated, and CT abdomen 27-months postsurgery demonstrated reduction in both masses to 0.8 × 2.4cm (right) and 1.5 × 4 cm (left), with resolution of the lymphadenopathy.Conclusion: RFN not associated with pancreatic disorders is rare, and only 5 cases have been reported in the literature. FN is a benign inflammatory process that can mimic the features of a malignant mass and almost always, a biopsy may be required for a definitive diagnosis. FN associated with significant weight loss following unilateral adrenalectomy for Cushing syndrome has not been reported in the literature. FN should be considered in the differential diagnosis of a mass appearing in an obese patient with substantial weight loss after surgery.Abbreviations: CT = computed tomography; FN = fat necrosis; HPE = histopathologic exam; RFNWP = retroperitoneal fat necrosis without pancreatic disorders |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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