The importance of the circadian trough in glucocorticoid signaling: a variation on B-flat

Autor: Onno C Meijer, Sander Kooijman, Jan Kroon, Elizabeth M Winter
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Stress, Vol 0, Iss 0, Pp 1-11 (2023)
Druh dokumentu: article
ISSN: 1025-3890
1607-8888
10253890
DOI: 10.1080/10253890.2023.2275210
Popis: Glucocorticoid hormones are essential for health, but overexposure may lead to many detrimental effects, including metabolic, psychiatric, and bone disease. These effects may not only be due to increased overall exposure to glucocorticoids, but also to elevated hormone levels at the time of the physiological circadian trough of glucocorticoid levels. The late Mary Dallman developed a model which allows the differentiation between the effects of overall 24-hour glucocorticoid overexposure and the effects of a lack of circadian rhythmicity. For this, she continuously treated rats with a low dose of corticosterone (or ‘B’), which leads to a constant hormone level, without 24-hour overexposure using subcutaneously implanted pellets. The data from this ‘B-flat’ model suggest that even modest elevations of glucocorticoid signaling during the time of the normal circadian trough of hormone secretion are a substantial contributor to the negative effects of glucocorticoids on health.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje