TNF and PGE2 in human monocyte-derived macrophages infected with Chlamydia trachomatis

Autor: E. Manor, E. Schmitz, I. Sarov
Jazyk: angličtina
Rok vydání: 1993
Předmět:
Zdroj: Mediators of Inflammation, Vol 2, Iss 5, Pp 367-371 (1993)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
09629351
DOI: 10.1155/S0962935193000511
Popis: In this study levels of prostaglandin E2 (PGE2), tumour necrosis factor (TNF) and interleukin-1 (IL-1) alpha in medium from monocyte derived macrophages (MdM) infected with Chlamydia trachomatis (L2/434/Bu or K biovars). TNF and PGE2 were found in both cases while IL-1 alpha was not detected. Both TNF and PGE2 levels were higher in the medium of the MdM infected with K biovars. TNF reached maximum levels 24 h postinfection, and then declined, while PGE2 levels increased continuously during the infection time up to 96 h post-infection. Addition of dexamethasone inhibited production of TNF and PGE2. Inhibition of PGE2 production by indomethacin resulted in increased production of TNF, while addition of PGE2 caused partial inhibition of TNF production from infected MdM.
Databáze: Directory of Open Access Journals
Externí odkaz: