| Autor: |
Olubisi E. Adeyi, David O. Babayemi, Babajide O. Ajayi, Akindele O. Adeyi, Ayomide H. Ayodeji, Adenike O. Oguntayo, Adenike T. Adeyemi, Oluwatoyin E. Olaiyapo, Shukurat T. Adeoye |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific African, Vol 11, Iss , Pp e00708- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2468-2276 |
| DOI: |
10.1016/j.sciaf.2021.e00708 |
| Popis: |
This study examined the effect of co-administration of sodium selenite (SS) and sodium arsenite (SA) on inflammation in rats. Thirty (30) male Wistar rats were separated into 6 groups of five animals each. Group I (control) was given distilled water, groups II, III, IV and V were exposed to 20 and 40 ppm SA in drinking water, but in addition to that, groups IV and V only were co-exposed with 0.25 mg/kg bwt SS, while group VI was exposed to 0.25 mg/kg bwt SS only orally. Following 5 weeks of exposure, levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) were increased in SA-exposed groups. Synergistic and antagonistic effects were observed in co-exposed groups depending on dose and the specific tissue being considered. Synergism was observed in tissues co-exposed to higher dose (40 ppm) of SA + 0.25 mg/kgbwt SS except in the liver, where these markers were decreased compared with control. Level of IL-10 (anti-inflammatory marker) decreased in all the tissues investigated except in the lungs of animals co-exposed with 40 ppm SA. There was alteration in tissue architecture, revealing steatosis and hemorrhagic lesions as the common features in co-exposed groups. Results obtained indicate that the dose of SS used in this study may be toxic and not therapeutic against SA-induced tissue inflammation in rats. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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