LXR agonism for CNS diseases: promises and challenges

Autor:	Ruiyi Zhang, Emily Wuerch, V. Wee Yong, Mengzhou Xue
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Liver X receptor Neurological diseases Neuroinflammation Cholesterol metabolism Tissue regeneration Clinical translation Neurology. Diseases of the nervous system RC346-429
Zdroj:	Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-13 (2024)
Druh dokumentu:	article
ISSN:	1742-2094
DOI:	10.1186/s12974-024-03056-0
Popis:	Abstract The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and overwhelming inflammation, while liver X receptor (LXR) may regulate both processes due to its pivotal role in cholesterol metabolism and inflammatory response, and thus receives increasing attentions from neuroscientists and clinicians. Here, we summarize the signal transduction of LXR pathway, discuss the therapeutic potentials of LXR agonists based on preclinical data using different disease models, and analyze the dilemma and possible resolutions for clinical translation to encourage further investigations of LXR related therapies in CNS disorders. Graphical Abstract
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/28fc2cc132ac453a943b5c9add5dc52a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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