Mapping of proteomic lysate of a MCF-7 cancer cell line for the identification of potential markers for breast cancer

Autor:	V. E. Shevchenko, M. A. Taipov, S. V. Kovalev, N. E. Arnotskaya, O. M. Pavlova, I. A. Kudryavtsev, Z. N. Nikiforova
Jazyk:	ruština
Rok vydání:	2014
Předmět:	breast cancer mcf-7 cancer cell line proteomics mass spectrometry biomarkers therapeutic targets Gynecology and obstetrics RG1-991
Zdroj:	Опухоли женской репродуктивной системы, Vol 0, Iss 2, Pp 4-10 (2014)
Druh dokumentu:	article
ISSN:	1994-4098 1999-8627
DOI:	10.17650/1994-4098-2012-0-2-4-10
Popis:	Mass spectrometric mapping of proteomic lysate of a MCF-7 cancer cell line was carried out, which identified 153 proteins having molecular weights of 5000 to 630000 Da, a high proportion of which was cytoplasmic and nuclear proteins. The latter accounted for 60 % of their total number whereas the proportion of extracellular and membrane proteins constituted 13 %. After using some selection criteria to analyze the findings, the authors present a list of 31 potential biomarkers and describe 12 promising breast anticancer therapeutic targets.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/2843f70f632b4c52b0ac271e7ea0f673 Zobrazit plný text záznamu View record in DOAJ