Elevated congenital heart disease birth prevalence rates found in Central Vietnam and dioxin TCDD residuals from the use of 2, 4, 5-T herbicides (Agent Orange) in the Da Nang region.

Autor: Hoang Thi Nam Giang, Tran Thanh Hai, Hoang Nguyen, Thanh K Vuong, Lois Wright Morton, Casey B Culbertson
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PLOS Global Public Health, Vol 2, Iss 10, p e0001050 (2022)
Druh dokumentu: article
ISSN: 2767-3375
DOI: 10.1371/journal.pgph.0001050
Popis: Congenital heart disease (CHD) birth prevalence rate in Da Nang City and two adjacent provinces in Central Vietnam reported by Giang et al. in 2019 was 20.09/1000 births, much higher than any CHD birth rates previously reported. In this current study, three physicians trained in pediatric cardiology reanalyzed and reclassified the Giang et al 2019 cardiac anomalies data, eliminating singular small PDAs and separating cardiac defects into 27 contemporary CHD subgroups. These CHD subgroups were then statistically compared with Liu et al. 2019 Global CHD birth prevalence study of Asian Low-Middle Income Countries (LMIC) CHD subgroup rate of 9.34/1000 births (95% CI 8.07-10.70). Despite applying newer diagnostic criteria and refining the cardiac anomalies data, the Da Nang region continued to show significantly (p
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