CRISPRoff enables spatio-temporal control of CRISPR editing

Autor: Jared Carlson-Stevermer, Reed Kelso, Anastasia Kadina, Sahil Joshi, Nicholas Rossi, John Walker, Rich Stoner, Travis Maures
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18853-3
Popis: Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.
Databáze: Directory of Open Access Journals