Complications after surgery for benign prostatic enlargement: a population-based cohort study in Ontario, Canada

Autor: Rano Matta, Erind Dvorani, Christopher Wallis, Amanda Hird, Joseph LaBossiere, Girish Kulkarni, Ronald Kodama, Lesley Carr, Sidney B Radomski, Refik Saskin, Sender Herschorn, Robert K Nam
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMJ Open, Vol 9, Iss 12 (2019)
Druh dokumentu: article
ISSN: 2044-6055
DOI: 10.1136/bmjopen-2019-032170
Popis: Objectives To examine the complication rates after benign prostatic enlargement (BPE) surgery and the effects of age, comorbidity and preoperative medical therapy.Design A retrospective, population-based cohort study using linked administrative data.Setting Ontario, Canada.Participants 52 162 men≥66 years undergoing first BPE surgery between 1 January 2003 to 31 December 2014.Intervention Medical therapy preoperatively and surgery for BPE.Primary and secondary outcome measures The primary outcome was overall 30-day postoperative complication rates. Secondary outcomes included BPE-specific event rates (bleeding, infection, obstruction, trauma) and non-BPE specific event rates (cardiovascular, pulmonary, thromboembolic and renal). Multivariable analysis examined the association between preoperative medical therapy and postoperative complication rates.Results The 30-day overall complication rate after BPE surgery was 2828 events/10 000 procedures and increased annually over the study period. Receipt of preoperative α-blocker monotherapy (relative rate (RR) 1.05; 95% CI 1.00 to 1.09; p=0.033) and antithrombotic medications (RR 1.27; 95% CI 1.22 to 1.31; p
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