Microsatellite unstable colorectal cancers are associated with increased CD1a- and CD83-positive dendritic cell infiltration

Autor:	Maya Gulubova, Elina Aleksandrova, Yovcho Yovchev, Dimitar Chonov, Petio Chilingirov, Tatyana Vlaykova
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	CRC microsatellite instability (MSI) dendritic cells immunohistochemistry prognostic factor survival Biotechnology TP248.13-248.65
Zdroj:	Biotechnology & Biotechnological Equipment, Vol 37, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	13102818 1314-3530 1310-2818
DOI:	10.1080/13102818.2023.2266517
Popis:	Microsatellite instability (MSI) is characterized by a highly immunogenic tumor phenotype and abundant lymphocytic infiltrates. The aim of this study was to investigate the association between four immunohistochemically determined classes of dendritic cells (DC) with microsatellite instability status of 258 colorectal cancer (CRC) patients and to explore the possible role of those cells as prognostic factors for survival. We observed a distinct infiltration pattern of DCs both in tumor stroma (TS) and invasive front (IF), with DCs significantly prevailing in the IF (p
Databáze:	Directory of Open Access Journals
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