Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Autor: Weikang Chen, Miao Yu, Shiji Chen, Tianmi Gong, Linlin Xie, Jinqin Liu, Chang Bian, Guolei Huang, Caijuan Zheng
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Fungi, Vol 10, Iss 3, p 190 (2024)
Druh dokumentu: article
ISSN: 10030190
2309-608X
DOI: 10.3390/jof10030190
Popis: The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylaria spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from Xylaria and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields.
Databáze: Directory of Open Access Journals
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