| Autor: |
Norah M. Alhoshani, Mohammed Al-Zharani, Bader Almutairi, Nada H. Aljarba, Norah S. AL-Johani, Nora Alkeraishan, Abdullah A. AlKahtane, Saud Alarifi, Daoud Ali, Saad Alkahtani |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Saudi Pharmaceutical Journal, Vol 30, Iss 11, Pp 1665-1671 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1319-0164 |
| DOI: |
10.1016/j.jsps.2022.09.011 |
| Popis: |
5-fluorouracil (5FU) is widely used to treat colorectal cancer (CC) and its main mechanisms of anticancer action are through generation of ROS which often result in inflammation. Here, we test the effect of Lycopene against 5FU in Caco2 cell line. Caco2 cells were exposed to 3 µg/ml of 5FU alone or with 60, 90, 120 µg/ml of lycopene. This was followed by assessment of cytotoxicity, oxidative stress, and gene expression of inflammatory genes. Our findings showed that Lycopene and 5FU co-exposure induced dose-dependent cytotoxic effect without compromising the membrane integrity based on the LDH assay. Lycopene also significantly enhanced 5FU-induced SOD activity and GSH level compared to control for all mixture concentrations (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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