Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats

Autor: Stephan Dreschers, Kim Ohl, Michael Lehrke, Julia Möllmann, Bernd Denecke, Ivan Costa, Thomas Vogl, Dorothee Viemann, Johannes Roth, Thorsten Orlikowsky, Klaus Tenbrock
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-09359-8
Popis: Neonatal immune responses are known to differ to those of an adult immune response. Here Dreschers and colleagues, compare macrophage populations derived from cord blood or adult peripheral blood and show a metabolic impairment of glycolysis in macrophages derived from cord blood which may impair response to infective scenarios such as sepsis.
Databáze: Directory of Open Access Journals