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Abstract Background Cancer is one of the leading causes of morbidity and mortality, worldwide. Little information is available for the temporal trends of cancer in the Mediterranean region, including Cyprus. Aims We aimed to analyze cancer incidence trends overall and by sex for the period 2004–2017 regarding the five most common cancer sites for the population of Cyprus. Methods and results Data were obtained from the nationwide cancer registry dataset that included 27 017 total cancer cases in Cyprus (2004–2017). We estimated the crude, sex‐, and age‐specific, as well as age‐standardized (ASR) cancer incidence rates and we analyzed the time trends of ASR using the joinpoint regression program. For the general population (0–85+ years of age), the most common cancer sites in descending order, were breast, prostate, lung, colorectal, and thyroid cancer. During the study period, breast and thyroid cancer ASR presented a significant (p |