Autor: |
Elvi Gil-Lievana, Gerardo Ramírez-Mejía, Oscar Urrego-Morales, Jorge Luis-Islas, Ranier Gutierrez, Federico Bermúdez-Rattoni |
Jazyk: |
angličtina |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Frontiers in Cellular Neuroscience, Vol 16 (2022) |
Druh dokumentu: |
article |
ISSN: |
1662-5102 |
DOI: |
10.3389/fncel.2022.823220 |
Popis: |
Taste memory involves storing information through plasticity changes in the neural network of taste, including the insular cortex (IC) and ventral tegmental area (VTA), a critical provider of dopamine. Although a VTA-IC dopaminergic pathway has been demonstrated, its role to consolidate taste recognition memory remains poorly understood. We found that photostimulation of dopaminergic neurons in the VTA or VTA-IC dopaminergic terminals of TH-Cre mice improves the salience to consolidate a subthreshold novel taste stimulus regardless of its hedonic value, without altering their taste palatability. Importantly, the inhibition of the D1-like receptor into the IC impairs the salience to facilitate consolidation of an aversive taste recognition memory. Finally, our results showed that VTA photostimulation improves the salience to consolidate a conditioned taste aversion memory through the D1-like receptor into the IC. It is concluded that the dopamine activity from the VTA into IC is required to increase the salience enabling the consolidation of a taste recognition memory. Notably, the D1-like receptor activity into the IC is required to consolidate both innate and learned aversive taste memories but not appetitive taste memory. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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