| Autor: |
Thilini S. Munasinghe, Megan R. Edwards, Sofiya Tsimbalyuk, Olivia A. Vogel, Kate M. Smith, Murray Stewart, Justin K. Foster, Loretta A. Bosence, David Aragão, Justin A. Roby, Christopher F. Basler, Jade K. Forwood |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-28851-2 |
| Popis: |
MERS-CoV ORF4b antagonizes host innate immune response, partially via blocking nuclear import adapter IMPα activity and preventing nuclear translocation of NF-κB. Here, Munasinghe and Edwards et al. biochemically and structurally define the interaction between ORF4b and IMPα-family members and find a non-canonical interaction between ORF4b NLS and IMPα2 and IMPα3. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink