| Autor: |
Suzanna J. Logan, Mark A. Edgar, Anthony P. Martinez |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Human Pathology: Case Reports, Vol 22, Iss , Pp 200458- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2214-3300 |
| DOI: |
10.1016/j.ehpc.2020.200458 |
| Popis: |
Soft tissue angiofibroma (STAF) is a benign fibrovascular neoplasm with a broad differential diagnosis including both benign and malignant tumors. This report expands the histologic spectrum of STAF with a case showing transition of conventional tumor morphology to distinct area of increased cellularity and cytologic atypia with diffuse, strong desmin expression, but absent myogenin and MYO-D1 expression. Mitotic figures were rare and necrosis was absent. These features have not previously been reported in STAF. A fusion was identified between AHRR and NCOA2 genes, which is a known, recurring feature of STAF. Sixteen months following resection with negative margins, there was no evidence of recurrence. Further reports of STAF showing similar findings with longer clinical follow-up are needed to determine the clinical significance of these results. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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