Remineralization of lytic spinal metastases after radiation therapy – A retrospective cohort study comparing conventional external beam radiation therapy with stereotactic ablative body radiation

Autor: Ruben Van den Brande, Maxim Van den Kieboom, Marc Peeters, Charlotte Billiet, Erik Van de Kelft
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Clinical and Translational Radiation Oncology, Vol 48, Iss , Pp 100805- (2024)
Druh dokumentu: article
ISSN: 2405-6308
DOI: 10.1016/j.ctro.2024.100805
Popis: Introduction: Osteolytic spinal metastases (SM) have a higher risk of fracture. In this study we aim to confirm the remineralization of lytic SM after radiation therapy. Secondary the influence of SBRT compared to cEBRT and tumor type will be analyzed. Methods: A retrospective cohort study was performed. Results: 87 patients, 100 SM were included. 29 received SBRT, 71 cEBRT. Most common primary tumors were breast (35 %), lung (26 %) and renal (11 %). Both cEBRT and SBRT resulted in a significant increase of bone mineral density (BMD) (83.76 HU ± 5.72 → 241.41 HU ± 22.58 (p
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