Could Lycopene Protect Against Ischemia/Reperfusion Injury in the Uterus?
| Autor: | Taylan Onat, Züleyha Doğanyiğit, Melike Demir Çaltekin, Can Türkler, Emin Kaymak, Mehmet Murat Altındağ |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | İstanbul Medical Journal, Vol 22, Iss 2, Pp 155-160 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2619-9793 2148-094X |
| DOI: | 10.4274/imj.galenos.2021.82698 |
| Popis: | Introduction:Ischemia/reperfusion damage (IRD) is one of the most important factors in the success of organ transplantation. IRD plays a role in both acute and chronic rejection. This study aims to evaluate the effects of lycopene, which is known to be a powerful antioxidant, on experimental uterine IRD.Methods:Twenty-four albino Wistar rats were included in the study and divided into three groups. No substances were administered the sham and ischemia/reperfusion groups. The ischemia/reperfusion and ischemia/reperfusion + lycopene groups were administered ischemia for 1 h and reperfusion for 2 h. The ischemia/reperfusion + lycopene group was administered 2.5 mg/kg lycopene reperfusion intraperitoneally half an hour before ischemia/reperfusion. Both uterine horns were extracted at the end of the procedure. Oxidative stress, inflammation, and apoptosis in the tissues were assessed.Results:The malondialdehyde level, nuclear factor kappa-B immunoreactivity, and apoptotic cell number in the lycopeneadministered group (ischemia/reperfusion + lycopene) were significantly decreased compared with those in the ischemia/ reperfusion group (p |
| Databáze: | Directory of Open Access Journals |
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