Highly Selective Synthesis of Chlorophenols under Microwave Irradiation

Autor: Yawen Xiong, Hongdong Duan, Xia Meng, Zhaoyun Ding, Weichun Feng
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of Chemistry, Vol 2016 (2016)
Druh dokumentu: article
ISSN: 2090-9063
2090-9071
DOI: 10.1155/2016/2960414
Popis: Oxychlorination of various phenols is finished in 60 minutes with high efficiency and perfect selectivity under microwave irradiation. These reactions adopt copper(II) chloride (CuCl2) as the catalyst and hydrochloric acid as chlorine source instead of expensive and toxic ones. Oxychlorination of phenols substituted with electron donating groups (methyl, methoxyl, isopropyl, etc.) at ortho- and meta-positions is accomplished with higher conversion rates, lower reaction time, and excellent selectivity. A proposed reaction mechanism is deduced; one electron transfers from CuCl2 to phenol followed by the formation of tautomeric radical that can be rapidly captured by chlorine atom and converts into para-substituted product.
Databáze: Directory of Open Access Journals
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