| Autor: |
Abdullah Nasser, Catherine L. Forse, Cynthia Walsh, Terence Moyana, Rakesh Goel |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Current Problems in Cancer: Case Reports, Vol 5, Iss , Pp 100144- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-6219 |
| DOI: |
10.1016/j.cpccr.2022.100144 |
| Popis: |
Background: Acinar cell carcinoma of the pancreas (ACC) is a rare malignancy, accounting for approximately 1-2% of all pancreatic cancers. Up to a quarter of ACCs are estimated to contain a significant component of another histology such as neuroendocrine or ductal adenocarcinoma. Prognosis and management remain uncertain for these mixed tumors. Case: A 71-year-old was initially diagnosed with biopsy-proven metastatic pancreatic ACC and treated with FOLFOX. Subsequent biopsy of a progressing metastatic site revealed ductal adenocarcinoma, and liquid biopsy showed a PRKAR1A-RAF1 fusion. The patient had a partial response to FOLFOX and died nine months after initial diagnosis. Discussion: This case highlights a metastatic presentation of mixed pancreatic acinar cell-ductal adenocarcinoma, its reasonable response to treatment with FOLFOX, and overall survival which was driven by the more aggressive ductal component. We also report the presence of a RAF1 rearrangement, which may present a possible therapeutic target in these rare tumors. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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