Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinoma

Autor: Manya Wu, Jinhui Jin, Zhenghuan Li, Fantu Kong, Yadi He, Lijiang Liu, Wei Yang, Xiangying Xu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PeerJ, Vol 10, p e13748 (2022)
Druh dokumentu: article
ISSN: 2167-8359
DOI: 10.7717/peerj.13748
Popis: Objective This study aimed to identify the effects of beamlet width on dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) and determine the optimal parameters for the most effective radiotherapy plan. Methods This study evaluated 20 patients with NPC were selected for dynamic IMRT. Only the beamlet width in the optimization parameters was changed (set to 2, 4, 6, 8, and 10 mm that were named BL02, BL04, BL06, BL08, and BL10, respectively) to optimize the results of the five groups of plans. Using the plan quality scoring system, the dose results of the planning target volumes (PTVs) and organs at risks (OARs) were analyzed objectively and comprehensively. The lower the quality score, the better the quality of the plan. The efficiency and accuracy of plan execution were evaluated using monitor units (MUs) and plan delivery time (PDT). Results The BL04 mm group had the lowest quality score for the targets and OARs (0.087), while the BL10 mm group had the highest total score (1.249). The BL04 mm group had the highest MUs (837 MUs) and longest PDT (358 s). However, the MUs range of each group plan was below 100 MUs, and the PDT range was within 30 s. In the BL02, BL04, BL06, BL08, and BL10 plans,
Databáze: Directory of Open Access Journals