New Directions in Transition Metal Catalyzed Carbonylation Chemistry
| Autor: | Dennis U. Nielsen, Karoline T. Neumann, Troels Skrydstrup |
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| Jazyk: | German<br />English<br />French |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | CHIMIA, Vol 72, Iss 9 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0009-4293 2673-2424 |
| DOI: | 10.2533/chimia.2018.606 |
| Popis: | Carbon monoxide (CO) represents an important C1-building block for the construction of some of the most fundamental chemical functionalities carrying a carbon–oxygen double bond. Transition metal catalysis plays a key role in promoting such transformations. We have earlier shown that the combination of palladium catalysis with CO releasing molecules and the two-chamber reactor, COware, provides a convenient and safe means for performing traditional Pd-catalyzed carbonylative couplings, as well as being a platform for the discovery of new carbonylation reactions. Furthermore, the method can be adapted to 13C- and 14C-isotope labeling, as well as providing for a suitable setting for developing efficient carbonylation reactions with 11CO. Herein, we provide a short overview of our latest findings in this area with emphasis on carbonylative couplings with fluorinated building blocks, but also discuss our efforts to develop viable Ni-catalyzed carbonylations with aliphatic substrates, which can be performed efficiently under low CO partial pressures. |
| Databáze: | Directory of Open Access Journals |
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