| Autor: |
Jun Wan, Samuel Block, Christina M. Scribano, Rebecca Thiry, Karla Esbona, Anjon Audhya, Beth A. Weaver |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-09471-9 |
| Popis: |
Mad1 is well characterised for its function in mitosis. Here, the authors describe an interphase role for Mad1 in tumour promotion in which it destabilises p53 by localizing to PML nuclear bodies and displacing MDM2 from the PML-MDM2 complex. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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