Protective effect of kavain in meristematic cells of Allium cepa L.
| Autor: | ERASMO P. DO VALE JUNIOR, MARCOS VITOR R. FERREIRA, BIANCA CRISTINA S. FERNANDES, THAIS T. DA SILVA, FRANCIELLE ALLINE MARTINS, PEDRO MARCOS DE ALMEIDA |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 94, Iss 2 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1678-2690 0001-3765 |
| DOI: | 10.1590/0001-3765202220200520 |
| Popis: | Abstract Kavain is one of the main kavalactones of Piper methysticum (Piperaceae) with anxiolytic, analgesic, and antioxidant activities. Therefore, the aim of the study was to evaluate the cytotoxic, mutagenic, and antimutagenic potential of kavain in Allium cepa cells. Roots of A. cepa were transferred to the negative (2% acetone) and positive (10 µg/mL of Methylmethanesulfonate, MMS) controls and to the concentrations of kavain (32, 64 and 128 µg/mL) for 48 h. A total of 5,000 meristematic cells were analyzed under an optical microscope to determine the mitotic index, mean number of chromosomal alterations and percentage of damage reduction. Data were analyzed by Kruskal-Wallis test (p |
| Databáze: | Directory of Open Access Journals |
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