| Autor: |
Hoang Le Tuan Anh, Nguyen Thi Cuc, Bui Huu Tai, Pham Hai Yen, Nguyen Xuan Nhiem, Do Thi Thao, Nguyen Hoai Nam, Chau Van Minh, Phan Van Kiem, Young Ho Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Molecules, Vol 20, Iss 1, Pp 1151-1160 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules20011151 |
| Popis: |
Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidines displayed weak cytotoxic effects against the tested cancer cell lines, but selective cytotoxic effects were observed. Compounds 3a and 3b showed the most selective cytotoxic effects against human epidermoid carcinoma (IC50 44.1 ± 3.6 μg/mL) and breast cancer (IC50 32.8 ± 1.4 μg/mL) cell lines, respectively. The results suggest that chromoylthiazolidines are potential low-cost, and selective anticancer agents. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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