Heterogeneity in genetic admixture across different regions of Argentina.

Autor: Sergio Avena, Marc Via, Elad Ziv, Eliseo J Pérez-Stable, Christopher R Gignoux, Cristina Dejean, Scott Huntsman, Gabriela Torres-Mejía, Julie Dutil, Jaime L Matta, Kenneth Beckman, Esteban González Burchard, María Laura Parolin, Alicia Goicoechea, Noemí Acreche, Mariel Boquet, María Del Carmen Ríos Part, Vanesa Fernández, Jorge Rey, Mariana C Stern, Raúl F Carnese, Laura Fejerman
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: PLoS ONE, Vol 7, Iss 4, p e34695 (2012)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0034695
Popis: The population of Argentina is the result of the intermixing between several groups, including Indigenous American, European and African populations. Despite the commonly held idea that the population of Argentina is of mostly European origin, multiple studies have shown that this process of admixture had an impact in the entire Argentine population. In the present study we characterized the distribution of Indigenous American, European and African ancestry among individuals from different regions of Argentina and evaluated the level of discrepancy between self-reported grandparental origin and genetic ancestry estimates. A set of 99 autosomal ancestry informative markers (AIMs) was genotyped in a sample of 441 Argentine individuals to estimate genetic ancestry. We used non-parametric tests to evaluate statistical significance. The average ancestry for the Argentine sample overall was 65% European (95%CI: 63-68%), 31% Indigenous American (28-33%) and 4% African (3-4%). We observed statistically significant differences in European ancestry across Argentine regions [Buenos Aires province (BA) 76%, 95%CI: 73-79%; Northeast (NEA) 54%, 95%CI: 49-58%; Northwest (NWA) 33%, 95%CI: 21-41%; South 54%, 95%CI: 49-59%; p
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