Mitoprotective effect of the receptor antagonist interleukin-1 in experimental cerebral stroke
| Autor: | E. V. Suprun |
|---|---|
| Jazyk: | English<br />Russian<br />Ukrainian |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Patologìâ, Iss 3, Pp 71-75 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2310-1237 2306-8027 |
| DOI: | 10.14739/2310-1237.2012.3.17019 |
| Popis: | Mitoprotective activity of the receptor antagonist of interleukin-1 ( RAIL-1, 7,5 mg/kg) comparing to Thiotriazoline (50 mg/kg) was studied on the model of experimental photoinduced cerebral thrombosis in rats. Against a background of RAIL-1 administration significant stabilization of mitochondria functional activity was noted (by blocking of mitochondrial pore opening) as wel as the state of thiol-disulfide system: normalization of activity of glutationperoxidase and glutationreductase, increase of levels of reduced forms of glutathione and thiols against a background of reduction of their oxidized forms. By mitochondrial activity RAIL-1 can be compared to Thiotriazoline and even exceeds it in some parameters. |
| Databáze: | Directory of Open Access Journals |
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